Abstract
Redistribution of polybrominated biphenyls (PBBs) during the recovery period following lactation resulted in concentrations of PBBs that were higher in mammary gland and lower in liver and fat than at the end of lactation. Hepatic arylhydrocarbon hydroxylase (AHH) and epoxide hydrolase (EH) activities were higher in PBB-treated rats during lactation than in the recovery period. However, transition from lactating to dry state had no effect on activity of mammary gland AHH in rats treated with PBBs. Microsomal enzyme activity and concentrations of PBBs in mammary gland and liver were reduced by nursing a second litter. Although redistribution and excretion of PBBs resulted in alterations in microsomal enzyme activity, all rats exposed to 100 ppm PBBs had microsomal enzyme activity in liver and mammary gland that was higher than that in controls. Persistent stimulation of mammary gland and hepatic microsomal enyzmes while mothers are exposed to PBBs may affect not only mothers and offspring suckling but subsequent progeny as well.
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