Abstract
Electrophysiological studies using reserpinized cats were performed to examine the effects of l- threo-3,4-dihydroxyphenylserine( l-threo-DOPS) on the noradrenergic pathway from the locus coeruleus (LC)_to the spinal trigeminal nucleus (STN). The spike generation of STN relay neurons induced by trigeminal nerve stimulation was not affected by LC conditioning stimulation nor iontophoretic application of l- threo-DOPS. After intraventricular administrayion of l- threo-DOPS, the inhibition of the spike generation was seen with LC conditioning stimulation and blocked by iontophoretically applied sotalol, suggesting that l-noradrenaline converted from l- threo-DOPS inhibits transmission of STN relay neurons.
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