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Abstract
The pharmacological effects of several amino acid precursors of putative neurotransmitters on putrescine levels in the brain and the liver of the rat were studied. L-DOPA increased brain and liver putrescine levels in a dose-dependent manner that reached its maximum effect in 4–6 h. The increase in liver putrescine was associated with a concomitant increase in ornithine decarboxylase activity. L-5-hydroxytryptophan increased liver putrescine but had no effect on brain putrescine levels. D-DOPA and D-5-hydroxytryptophan were both ineffective in altering brain or liver putrescine. The effects of L-DOPA persisted after hypophysectomy and were not associated with changes in tissue levels of S-adenosylmethionine. The repeated administration of L-DOPA for periods of 48 and 96 h resulted in a sustained elevation of putrescine levels in the brain but not in the liver.
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