Abstract
Rats were orally given L-Dopa and chlorpromazine (CPZ) both separately and in combination for four days, after which time a number from each group were injected i.p. with 0.025 mg of apomorphine. 25 min after the injection the rats were killed and the levels of DA, NA, 5-HT and free amino acids (FAA's) were determined in the brain. l-dopa treatment resulted in an increase in DA, NA, 5-HT and FAA levels and apomorphine potentiated this effect with respect to levels of FAA's. Although CPZ potentiated the effect of l-Dopa on the levels of NA and 5-HT, it inhibited the l-Dopa related increases in the DA and FAA levels. In the case of rats, administered both l-Dopa and CPZ, apomorphine injection reversed, to a great extent, the effect of l-Dopa on FAA levels, possibly due to the inhibition of DA release through the stimulation of presynaptic DA receptors, whereas it caused a further increase in the levels of DA and 5-HT. In the light of the present and previous findings it is suggested that DA may be one of the major factors which regulate the levels of FAA's in the brain.
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