Abstract
Background: L-carnitine therapy has a potential role in lipid metabolism and glucose homeostasis. Despite its promising effects, further investigation is warranted. This study aimed to determine the impact of L-carnitine therapy of low and high doses on fat and glucose metabolism of albino Wistar rats after Meldonium induced carnitine depletion. Methods: A total number of 48 albino Wistar rats were recruited and divided into four groups 12 rats in each group. The bedding material was changed every second day and all animals were given Kaytee Supreme Fortified Daily Diet rat food and clean distal water ad libitum at room temperature. The experiment was commenced after 10 days of acclimatization. Results: Both high (300 mg/Kg) and low-dose (500 mg/Kg) L-carnitine significantly improved (p<0.05) blood glucose levels, TC, LDL, and HDL after four weeks of L-carnitine therapy. However, high-dose therapy showed significantly higher HDL improvements and decreased TC and LDL levels than low-dose therapy (p<0.05) among Meldonium carnitine-depleted rats. Conclusion: L-carnitine high dose therapy (500 mg/Kg of body weight) had a more potent effect on lipid profile in comparison to low dose (300 mg/Kg of body weight). Pak J Physiol 2024;20(1):26-9
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
