Abstract
The aim of the present study was to investigate the beneficial effectsof L-carnitine and taurine in healthy and alloxan induced diabetes mellitusin rats. Results showed that diabetic rats had significant increase in thelevels of plasma glucose, malondialdehyde (MDA), urea, creatinine andthe activity of serum asparate aminotransferase and alanineaminotransferase as compared to normal control rats. While, bloodglutathione (GSH) content and erythrocyte superoxide dismutase (SOD)activity were significantly lowered. The elevated plasma glucose, MDA,AST, ALT, urea and creatinine levels of diabetic rats were significantlyreduced by treatment for 6weeks with L-carnitine and taurine. In addition,normal healthy rats fed on the balanced diet plus L-Carnitine and taurineshowed significant increase in blood glutathione (GSH) content anderythrocyte superoxide dismutase (SOD) activity as compared withhealthy control. It was concluded that dietary administration of L-carnitineand taurine reduces, delays or even prevent oxidative stress in diabeticrats.Keywords: Alloxan induced diabetes, L-carnitine, taurine, blood glucose,lipid peroxidation, liver and kidney functions.
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