Effects of ketorolac tromethamine on postoperative analgesia in children with fractures

Abstract

Objective To investigate the effects of ketorolac tromethamine on analgesia after orthopaedic surgery in children. Methods A total of 42 children who underwent fracture internal fixation in People’s Hospital of Xishuangbanna Dai Autonomous Prefecture from January 2017 to December 2017 were randomly selected and were divided into group A and group B according to random number table method, with 21 cases in each group. Patients in group A and group B were given a loading dose of sufentanil (0.05 mg/kg) and ketorolac tromethamine (0.5 mg/kg) at 20 minutes before the end of surgery; and an analgesic pump was connected after surgery, the protocol for patients in group A was 2 μg/kg sufentanil plus 0.15 mg/kg ondansetron, while 0.5 mg/kg ketorolac tromethamine plus 1.50 μg/kg sufentanil plus 0.15 mg/kg ondansetron diluted to 100 ml in total were used for patients in group B. The intraoperative and postoperative conditions of adverse reactions were observed and compared between the two groups. Results Compared with group A, the pain scores at extubation immediately and 6, 12, 24, 48 hours after operation in group B were reduced (P<0.05), and the frequency of patient-controlled analgesia (PCA) decreased (P<0.05), the interval of pressing was prolonged (P<0.05). The incidence of vomiting and skin itching in group B was lower than that in group A (P<0.05). Conclusions Ketorolac tromethamine and sufentanil can significantly alleviate the pain after pediatric fracture and reduce the requirements for opioids after surgery in children, with fewer adverse reactions. Key words: Ketorolac tromethamine; Children; Fractures; Postoperative pain