Abstract
Effects of Ivermectin, Chloroquine or Artemether on some serum biochemical constituents in zebu cattle naturally infected with Onchocerca gutturosa in the Sudan
Highlights
Onchocerca spp. of cattle namely Onchocerca gibson; Onchocerca gutturosa; Onchocerca lienalis and Onchocerca ochengi have been used for studies involving in vivo testing of potential new macrofilaricidal compounds (Trees et al, 2000)
This study was undertaken to examine the effects of repeated doses of Ivermectin, Chloroquine or standard dose Artemether on some serum biochemical parameters in calves naturally infected with O. gutturosa for possible changes that may occur following medication
Pretreatment mean values of total protein, albumin and globulins were similar in all groups; the observed increases post treatment in total protein and globulins were not significant (P>0.05) and were within the normal range reported for zebu cattle
Summary
Onchocerca spp. of cattle namely Onchocerca gibson; Onchocerca gutturosa; Onchocerca lienalis and Onchocerca ochengi have been used for studies involving in vivo testing of potential new macrofilaricidal compounds (Trees et al, 2000). This study was undertaken to examine the effects of repeated doses of Ivermectin, Chloroquine or standard dose Artemether on some serum biochemical parameters in calves naturally infected with O. gutturosa for possible changes that may occur following medication. RESULTS and DISCUSSION Injection of Artemether and Ivermectin showed a rapid and almost 100% clearance of skin microfilariae of O. gutturosa in calves within the first 2-3 days of treatment as shown in Tables (2 and 3).
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