Abstract
Intravenous fluid therapy has long been the mainstay of treatment of kidney disease, including acute kidney injury and uremic crisis associated with chronic kidney disease. Careful management of fluid dose is critical, as animals with kidney disease may have marked derangements in their ability to regulate fluid homeostasis and acid-base status. Understanding of the physiology of renal fluid handling is necessary, along with repeated attention to parameters of fluid status, electrolytes, and acid-base balance, to achieve optimal hydration status and avoid further damage or decrease in function from dehydration or overhydration.
Highlights
Fluid therapy is the most commonly administered intravenous treatment for hospitalized veterinary patients
Renal tubular injury is associated with a decrease in glomerular filtration rate (GFR) and is divided into different phases of Acute kidney injury (AKI), which are directly related to the cellular events that occur during the injury and recovery process
The clinician is forced to walk a tight rope between too few fluids, which can lead to further progression of AKI from ongoing renal ischemia, and too much fluids leading to systemic complications and organ dysfunction
Summary
The Ohio State University College of Veterinary Medicine, Columbus, OH, United States. Intravenous fluid therapy has long been the mainstay of treatment of kidney disease, including acute kidney injury and uremic crisis associated with chronic kidney disease. Careful management of fluid dose is critical, as animals with kidney disease may have marked derangements in their ability to regulate fluid homeostasis and acid-base status. Understanding of the physiology of renal fluid handling is necessary, along with repeated attention to parameters of fluid status, electrolytes, and acid-base balance, to achieve optimal hydration status and avoid further damage or decrease in function from dehydration or overhydration. Specialty section: This article was submitted to Comparative and Clinical Medicine, a section of the journal Frontiers in Veterinary Science
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