Abstract
Two purine immunoenhancing drugs, isoprinosine and NPT 15392, were evaluated as inducers of IL-2 or enhancers of IL-2 induction by phytohemagglutinin (PHA). Both drugs were found to have significant enhancing activity on PHA induction of IL-2 by human lymphocytes over a wide range of concentrations. Alone they were unable to consistently induce IL-2 activity. NPT 15392 was able to enhance PHA-induced IL-2 production at 10–100 times lower concentrations than isoprinosine. The actions of these compounds to enhance IL-2 production may explain their effects on PHA-induced lymphocyte proliferation.
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