Abstract
The suppressive activity of isoflavonoids against lymphocyte proliferationin vitro was examined. Isoflavonoid derivatives tested were isoflavones isolated fromPueraria radix and synthesized 7-O-substituted biochanin A derivatives. The certain isoflavones such as biochanin A and 2-carbethoxybiochanin A were found to possess the suppressive activity against concanavaline A (Con A)-induced lymphocyte proliferation from mouse spleen. Against mixed lymphocyte culture reaction, biochanin A, 2-carbethoxybiochanin A, daidzein, formononetin, genistein and 7-O-isopropylbiochanin A showed the suppressive activity at 10−5 M. However, all isoflavones tested did not show the suppressive activity against lymphocyte proliferation induced by B-cell mitogen, lipopolysaccharide (LPS). In general, isoflavones were revealed to be less active than flavones/flavonols.
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