Effects of iso-osmolar contrast media on renal function in elderly patients

Abstract

Objective To investigate the effect of iso-osmolar contrast media (IOCM) on renal function in elderly patients. Methods The clinical data of 77 patients aged over 65 years undergoing vascular angiography and interventional therapy using IOCM with a dose>100 ml from September 2016 to May 2017 were retrospectively analyzed. Serum creatinine (CRE), urea and uric acid were measured before angiography, within 48 h and 3-7 d after angiography. The incidence of contrast-induced nephropathy (CIN) and the renal function before and after angiography were compared. Results Among the 77 patients, 58 were males and 19 were females, with an average age of (73.8±7.2) years. The mean serum CRE values before and 3-7 days after angiography were (84.55±39.92) μmol/L and (83.87±38.45) μmol/L respectively (t=0.140, P=0.889); the mean serum urea levels were (5.64±2.36) mmol/L and (6.44±3.15) mmol/L (t=3.041, P=0.003); the mean serum uric acid levels were (281.39±85.30) μmol/L and (333.29±89.89) μmol/L (t=7.297, P<0.001), respectively. CIN occurred in 7 patients with an incidence of 9.1%. In 7 patients with CIN, the mean CRE values increased from (135.71±102.41) μmol/L before angiography, to (180.00±100.45) μmol/L within 48 h and (142.86±92.97) μmol/L 3-7 d after angiography (F=9.876, P=0.011); and the uric acid levels progressively decreased from (353.43±86.73) μmol/L before angiography, to (339.14±85.69) μmol/L within 48 h after angiography and (299.57±95.71) μmol/L 3-7 d after angiography (F=5.713, P=0.029). Conclusion In elderly patients, IOCM has relatively mild effect on renal function during vascular angiography or interventional therapy. Key words: Contrast media; Aged; Acute kidney injury