Abstract
Objective To investigate the effect of ischemia/reperfusion (I/R) injury on immunogenicity of the liver. Methods Thirty rats were randomly divided into three groups. The levels of B7 were assayed by using immunochemistry and Western blotting in the 30 min I/R group, 60-min I/R group, and control group. Results The levels of B7-1 and B7-2 were very low in normal liver tissues (0.035 ± 0. 005, 0. 025 ± 0. 004) , but markedly increased after I/R injury ( P < 0.01). The levels of B7-1 and B7-2 in the 60 min I/R group were higher than those in the 30 min I/R group (B7-1:0. 070 ± 0. 017 vs 0. 051 ± 0. 008, B7-2:0. 042 ± 0.004 vs 0. 037 ± 0.004; both P<0.01). Conclusion I/R injury increased the immunogenicity of the liver by up-regulating the costimulatory molecule B7, promoting the development of acute rejection. Key words: Liver; Ischemia; Reperfusion injury; Immunogenicity
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