Abstract
The ionophores A23187 and X537A inhibit 45Ca uptake by rabbit brain mitochondria and synaptosomes and also stimulate the release of accumulated 45Ca from these preparations, but have no effect on 45Ca binding by synaptic membranes or on total brain Ca in mice. Both agents inhibit uptake and stimulate release of 3H-norepinephrine by rabbit P 2 synaptosomal preparations, while the NE and serotonin levels of mouse brain are depressed by X537A. The changes in Ca activities may be related both to the elevated thresholds for cortical after-discharge produced in cats by these ionophores, and to the ionophore induced reduction of pentylenetetrazol seizures in mice.
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