Abstract
The carcinogenic action of ionizing radiation in humans has been well recognized from epidemiologic data. Despite this fact there has been only one report on the radiogenic transformation of human epithelial cells (1). We have established immortalized, non-tumorigenic human bronchial epithelial cell lines following transfection with human papillomaviruses (HPV) 16 or 18 (2) and are employing them in experiments designed to identify genetic mechanisms involved in neoplastic transformation of human bronchial epithelial cells by ionizing radiation. The specific investigations are 1) analysis for specific genetic alterations in transformants (cells that have altered morphology, growth in soft agar or tumorigenicity in immunosuppressed mouse); and 2) identification of mechanisms involved in differentiation of human bronchial epithelial cells by evaluation of the differentiation-specific transcription of the E6/E7 transforming genes in radiated cells.
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