Abstract
A single cerebral intranventricular injection of 6-hydroxydopamine hydrochloride (6-OHDA; 170 mcg free base) dissolved in .001 N-HCl was given to male rats in order to study the involvement of central catecholaminergic neurons in tonic gonadotropin release. Following treatment the animals showed significantly reduced (p less than .001) luteinizing hormone (LH) levels after 1 hour. LH remained consistently lower for 8 hours. Control rats which received solvent alone experinced no change in LH except for a transient elevation following injection. No difference in LH level was seen between experimental and control groups at 2 days postinjection or later. Follicle stimulating hormone patterns were not as consistently different. Similar results were achieved when 6-OHDA was administered dissolved in different vehicles with varied pH and osomolarity suggesting that the quinone derivative of 6-OHDA effectively produces catecholaminergic impairment. These data indicate that LH release in the male rat may be controlled or modulated by a central adrenergic mechanism.(AUTHORS MODIFIED)
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