Effects of intraventricular injection of bradykinin on the EEG and the blood pressure in conscious rats

Abstract

In the conscious rat, a possible correlation between the changes in behavior, electroencephalogram (EEG) and the mean blood pressure were investigated to further study the central action of bradykinin (BK). Intraventricular injection of BK causes short-lasting excitation followed by sedation. The initial phase is associated with EEG, desynchronization of the neocortex, the limbic system and especially, the rhythmical slow activity (RSA) in the hippocampal EEG. The secondary phase is associated with the initial desynchronization, containing some spikes and the subsequent synchronization of EEGs. Furthermore, a dual pressor response consisting of two peaks was also produced by BK which coincided with the biphasic behavioral change.