Abstract
Objective To compare the effects of intravenous inhalation compound anesthesia and total intravenous anesthesia on perioperative inflammatory cytokines in patients with breast cancer.Methods Sixty breast cancer patients underwent cholecystectomy were randomly divided into intravenous inhalotion compound group (group Ⅰ) and total intravenous anesthsia group (group Ⅱ),with 30 cases in each group.Blood samples were collected before induction of anaesthesia,at 4,24 hours after skin incision.The serum levels of IL-6 and TNF-α were detected by enzyme-linked immunosorbent assay (ELISA).Results The serum levels of IL-6 and TNF-α were significantly higher at 4,24 hours after skin incision,compared with those before anethesia in both groups (P ＜0.05).The serum levels of IL-6 and TNF-α at 4,24 hours after skin incision were significantly lower in group Ⅰ than those in group Ⅱ(P ＜0.05).Conclusious The total intravenous anesthesia can reduce the stress response during peri-operation period effectively than the intravenous inhalation compound anesthesia by reducing the serum levels of IL-6 and TNF-α in patients with breast cancer. Key words: Total intravenous anesthesia; Intravenous inhalation compound anesthesia; Interleukin-6; Tumor necrosis factor-alpha
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
