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Abstract
BackgroundIntravenous lidocaine has been shown to reduce opioid consumption and is associated with favourable outcomes after surgery. In this study, we explored whether intraoperative lidocaine reduces intraoperative opioid use and length of stay (LOS) and improves long-term survival after primary debulking surgery for ovarian cancer and explored the correlation between SCN9A expression and ovarian cancer prognosis.MethodsThis retrospective study included patients who underwent primary debulking surgery(PDS) for ovarian cancer from January 2015 to December 2018. The patients were divided into non-lidocaine and lidocaine [bolus injection of 1.5 mg/kg lidocaine at the induction of anaesthesia followed by a continuous infusion of 2 mg/(kg∙h) intraoperatively] groups. Intraoperative opioid consumption, the verbal numeric rating scale (VNRS) at rest and LOS were recorded. Propensity score matching was used to minimize bias, and disease-free survival (DFS) and overall survival (OS) were compared between the two groups.ResultsAfter propensity score matching(PSM), the demographics were not significantly different between the groups. The intraoperative sufentanil consumption in the lidocaine group was significantly lower than that in the non-lidocaine group (Mean: 35.6 μg vs. 43.2 μg, P=0.035). LOS was similar between the groups (12.0 days vs. 12.4 days, P=0.386). There was a significant difference in DFS between the groups (32.3% vs. 21.6%, P=0.015), and OS rates were significantly higher in the lidocaine group than in the non-lidocaine group (35.2% vs. 25.6%, P=0.042). Multivariate analysis indicated that intraoperative lidocaine infusion was associated with prolonged OS and DFS.ConclusionIntraoperative intravenous lidocaine infusion appears to be associated with improved OS and DFS in patients undergoing primary debulking surgery for ovarian cancer. Our study has the limitations of a retrospective review. Hence, our results should be confirmed by a prospective randomized controlled trial.
Highlights
Ovarian cancer ranks third among the most common gynaecologic tumours and is the eighth leading cause of cancer-related death in women in developing countries [1]
Since lidocaine acts on sodium voltage channels, we explored the association between SCN9A gene expression and long-term prognosis in ovarian cancer patients
Univariate Cox regression analysis showed that age, American Society of Anaesthesiologists (ASA) score, Charlson Comorbidity Index (CCI), tumour differentiation, FIGO stage, residual disease, surgical complexity, ascites, intraoperative blood loss, adjuvant chemotherapy and lidocaine infusion were associated with overall survival (OS) (Table 2)
Summary
Ovarian cancer ranks third among the most common gynaecologic tumours and is the eighth leading cause of cancer-related death in women in developing countries [1]. Despite significant progress in the treatment of ovarian cancer, the 5-year survival rate remains lower than 50% [2]. This worrisome statistic highlights the urgent need to find therapies that can contribute to reducing ovarian cancer progression and improve patient survival. Preclinical and clinical studies suggest that anaesthetic agents may influence cancer biology and outcomes [3]. Intravenous lidocaine has been shown to reduce opioid consumption and is associated with favourable outcomes after surgery. We explored whether intraoperative lidocaine reduces intraoperative opioid use and length of stay (LOS) and improves long-term survival after primary debulking surgery for ovarian cancer and explored the correlation between SCN9A expression and ovarian cancer prognosis
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