Abstract
The effects of 24 hr intravenous infusion of dopamine in 9 cirrhotic patients without azotemia and one patient with mildly elevated BUN were studied. Dopamine (3, 4-dihydroxyphenylethylamine) 2 μg/kg/min produced statistically significant decrease in creatinine clearance and urine osmolarity, and an increase in urinary sodium excretion of borderline significance. These could be attributed to “shunting” of blood from the renal cortex to the medulla brought about by dopamine. This effect was reversible when the drug infusion was discontinued. The therapeutic value of dopamine in hepatorenal syndrome is therefore being questioned.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
