Effects of intravenous human plasmin on the blood clotting mechanism of the dog.

Abstract

Abstract These studies suggest that plasmin in sufficient concentration may alter all 3 phases of the clotting mechanism in vivo. These changes are discussed with respect to the clotting abnormality associated with excessive fibrinolysis seen in some patients with a hemorrhagic diathesis. Satisfactory time-dosage infusion data for cautious administration of plasmin to humans have been presented. If satisfactory proteolytic degradation of intravascular clots can be safely obtained with plasmin, it may prove to be a valuable therapeutic agent in certain cases of thromboembolism.