Effects of intravenous administration of tranexamic acid and joint cavity injection of tranexamic acid on blood loss in total knee arthroplasty

Abstract

Objective To investigate the application of intravenous administration of tranexamic acid and joint cavity injection of tranexamic acid in total knee arthroplasty and its effect on postoperative blood loss. Methods A total of 90 patients underwent total knee arthroplasty from Jan. 2016 to Dec. 2017 were recruited as study subjects. They were divided into intravenous administration group (n=44) and joint cavity administration group (n=46) according to different modes of administration. The clinical treatment effects and blood loss of the two groups were observed. Results The total erythrocyte loss, visible erythrocyte loss, occult red cell loss, and transfused erythrocytes in intravenous administration group were significantly higher than those in joint cavity group (P<0.05). The levels of PT, APTT, TT and FIB in the two groups significantly improved compared with those before surgery, and the degree of improvement in the joint cavity group was better than that in the intravenous group (P<0.05). The postoperative incidence of complications (9.09%) in intravenous administration group, which was significantly lower than that in joint cavity administration group (2.17%, P<0.05). Conclusions The use of intra-articular injection of tranexamic acid in total knee arthroplasty is superior to that of intravenous therapy in clinical total knee arthroplasty, which can reduce the blood loss and postoperative complications, so it is worthy of clinical application and promotion. Key words: Total knee arthroplasty; Tranexamic acid; Intravenous infusion; Intra-articular injection; Blood loss