Effects of intraruminal loads of saline or water followed by voluntary drinking in the dehydrated lactating goat

Abstract

In five goats water deprivation for 26 h increased plasma osmolality, total plasma protein concentration, and plasma vasopressin (AVP) concentration to higher levels during lactation compared to nonlactation. At the end of the dehydration period intraruminal loads of saline or water (corresponding to 50% of the body weight loss) were given to lactating goats. The saline load decreased the plasma protein concentration below control levels, while plasma osmolality, Na concentration and AVP did not change. After the water load the plasma protein concentration stayed elevated. Plasma osmolality, Na concentration and AVP fell, but remained significantly above control levels. Both plasma renin activity (PRA) and aldosterone (PA) concentration increased after water, but decreased after saline administration. Three hours after the fluid loads the goats were offered water to drink. AVP decreased at the sight of water. After drinking, plasma osmolality, Na and AVP continued to decrease in water loaded animals, and fell also in saline loaded goats. PRA remained elevated, and PA increased in water loaded goats, while these hormones still were depressed in saline loaded goats. Mean renal 'free water clearance' became positive after drinking in both groups. It is concluded that the water losses with the milk cause lactating goats to become dehydrated more rapidly than non-lactating goats during water deprivation. Lowering of the plasma osmolality and Na concentration are more important than restoration of the plasma volume in suppressing the high plasma AVP concentration in the dehydrated lactating goat. The water diuresis, which occurred after voluntary drinking, indicates that the goats had not been able to anticipate their water deficit accurately.(ABSTRACT TRUNCATED AT 250 WORDS)