Abstract
Intraventricular and intraperitoneal administration of d-amphetamine impaired asymptotic shuttle box avoidance performance in rats. Low ip doses (0.5, 1.0, 1.5, and 2.0 mg/kg) had no effect whereas higher ip doses (2.5, 3.0, 3.5, 4.0 mg/kg) impaired performance in a dose-related fashion. An inverted U-shaped function was obtained with the ivent doses; low dose (25 ug) and high doses (200 and 400 ug) impaired performance whereas intermediate doses (50 and 100 ug) had little effect. The cannulation procedure itself produced only minimal acquisition effects. The data tend to support the contention that amphetamine acts on the brain to cause the deterioration of well learned avoidance responding.
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