Abstract
Catheter-related bladder discomfort (CRBD) is one of the most difficult symptoms during the postoperative period. Nefopam is a non-narcotic analgesic agent, which also has anticholinergic action. This study was performed to evaluate the effects of nefopam on CRBD in male patients undergoing robotic nephrectomy. A total of 109 male patients were randomly divided into two groups: the control group (n = 55) received 20 mL of normal saline, and the nefopam group (n = 54) received 20 mg of nefopam 1 h before the end of the operation. At postoperative times of 20 min, 1 h, 2 h, and 6 h, the severity of CRBD was measured using an 11-point numeric rating scale, respectively. The severity of CRBD in the nefopam group was significantly lower than that in the control group at 20 min (4.8 ± 1.3 vs. 2.3 ± 1.0, respectively, p = 0.012) and at 1, 2, and 6 h (3.5 ± 1.2, 2.7 ± 0.9, and 2.5 ± 1.0 vs. 4.1 ± 0.8, 1.6 ± 0.8, and 1.3 ± 0.6, respectively, p < 0001). Intraoperative nefopam administration reduced the severity of CRBD in patients undergoing robotic nephrectomy.
Highlights
The Catheter-related bladder discomfort (CRBD) induced by urethral catheterization is defined as an unpleasant and burning sensation in the urethra and suprapubic area, causing an impulse to void and urinary frequency [1,2,3]
This randomized, controlled trial was performed to evaluate the effects of intraoperative nefopam on CRBD in patients undergoing robotic nephrectomy
The results of this study indicate that postoperative CRBD was relieved by the intraoperative administration of nefopam (20 mg) before the end of surgery without any side effects
Summary
The Catheter-related bladder discomfort (CRBD) induced by urethral catheterization is defined as an unpleasant and burning sensation in the urethra and suprapubic area, causing an impulse to void and urinary frequency [1,2,3]. When the patient is ambulating for recovery after surgery, the catheter can severely irritate the bladder, causing pain and discomfort, which may delay the patient’s recovery. CRBD is caused by involuntary contraction of the bladder, which involves the M3 receptors in the bladder wall near the catheter [7]. We hypothesized that the anticholinergic effect of nefopam may reduce the severity of CRBD. This randomized, controlled trial was performed to evaluate the effects of intraoperative nefopam on CRBD in patients undergoing robotic nephrectomy
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