Abstract
A trial was carried out on acidotic infants recovering from neonatal asphyxia, on the relative effects of intragastric and intravenous sodium bicarbonate on acid/base balance. Intragastric bicarbonate caused an increased rate of correction of metabolic acidosis within 30 minutes of administration. However, the Pco<sub>2</sub> remained higher in these patients than in the controls, so that the effect of the bicarbonate on rate of <i>p</i>H correction was negligible. The rise in Pco<sub>2</sub> occurred despite apparently normal respiratory function. A similar limitation of <i>p</i>H rise by a sustained rise in Pco<sub>2</sub> was evident in the intravenously treated patients. Treatment of metabolic acidosis in neonates with sodium bicarbonate may not produce the desired correction of <i>p</i>H.
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