Abstract
Acne vulgaris is a common condition that can have psychologically deleterious effects. Since current treatments carry the risks of antibiotic resistance or teratogenicity, novel treatment modalities are under investigation. Our study investigated the efficacy of intradermal radiofrequency treatment (RF) and intense pulsed light (IPL) in the treatment of acne vulgaris in a rabbit ear model. We evaluated the effectiveness of IPL, RF, and a combination treatment on cultured Cuticobacterium acnes strains in an induced rabbit ear model, according to clinical outcomes as well as histological and immunological approaches. We found that RF treatment markedly decreases papule volume, while IPL appears to have an immunomodulatory effect. In combination, the two have an additive effect in treatment. These findings suggest that combination of RF and IPL may be an effective therapeutic option for the treatment of acne vulgaris.
Highlights
Peroxisome proliferator-activated receptor-gamma (PPAR-γ) is a lipid-activated nuclear hormone receptor participating in sebaceous lipogenesis and differentiation in addition to inflammation[22,23,24]
Differences between bacteria treated by single therapies, such as RF or intense pulsed light (IPL), and those treated by combination therapy, were apparent
Previous studies have shown that RF reduces sebum production through the selective electrothermolytic destruction of sebaceous glands[29,30,31], wherein the glands are subsequently replaced by fibrosis, leading to dermal contraction and resulting in skin tightening and pore size reduction[31]
Summary
Peroxisome proliferator-activated receptor-gamma (PPAR-γ) is a lipid-activated nuclear hormone receptor participating in sebaceous lipogenesis and differentiation in addition to inflammation[22,23,24]. Sebaceous glands express PPAR-γ, and a number of eicosanoids are capable of triggering this transcriptional factor in vitro[22,24] In both acne lesions and non-acne lesions of acne patients, PPAR-γ is either low or absent in the sebaceous glands[25]. Lipid production within acne sebaceous glands is greater than in healthy sebaceous glands This suggests that in sebaceous glands of acne lesions, the primary effect of PPAR-γ may be to regulate inflammation, and possibly to maintain balanced lipid production[25]. IPL is commonly used to treat pigmentary disorders and for epilation It is sometimes used in photodynamic therapy of acne, its performance is questionable, and its efficacy and applicability require further investigation[26,27,28]. We aimed to assess the effectiveness of IPL, RF, and a combination of the two on C. acnes strains and using an acne-induced rabbit ear model
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