Abstract
The effects of ICV injections of DSIP and ω-amino-caprilyl-DSIP (C-DSIP) on the sleep-wake activity and brain temperature (T br were studied in rats. The substances (7 nmol/kg) were injected at dark onset, and the sleep-wake activity and T br were recorded for 24 hr (dark and light periods, 12 hr each). Relative to the control recordings obtained after artificial CSF injection, the duration of sleep did not increase after either DSIP or C-DSIP. The only significant reaction was an increase of W 6 to 9 hr after the injection of either peptide. The course of T br after DSIP and C-DSIP was also indentical to that recorded after the injection of artificial CSF. It seems that DSIP administered in a single ICV injection at dark onset does not promote sleep. The increase in W might be attributed to an indirect effect of DSIP or to a degradation product of the peptide.
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