Abstract
Intraaortic balloon Counterpulsation was carried out in 10 anesthetized normotensive dogs after ligation of the left anterior descending coronary artery. The distribution of myocardial blood flow was determined in these animals by the radioactive microsphere technique. Counterpulsation resulted in a significant decrease in mean arterial pressure of 29 mm Hg ( P < 0.001) and an increase of 20 mm Hg in peak and 10 mm Hg in mean aortic diastolic pressure ( P < 0.005). There was no direct relation between the hemodynamic effects of counterpulsation and improvement in the distribution of myocardial blood flow to the infarcted area of myocardium. Analysis of data from individual experiments suggests that improvement in myocardial blood flow to the infarcted region is dependent upon the presence of preexisting collateral vessels, since animals with the highest rates of flow to the infarcted region after ligation of the left anterior descending coronary artery had the greatest increase in myocardial blood flow after intraaortic balloon counterpulsation. Despite the failure of any overall improvement in myocardial blood flow to the infarcted area after Counterpulsation, there was a small but significant relative increase in endocardial flow to the normal and border zones of myocardium surrounding the infarcted region.
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