Abstract
To investigate the role of ovarian endogenous eicosanoids in regulation of luteal function, we examined effects of local and chronic administration of eicosanoid synthesis inhibitors on plasma progesterone levels in immature pseudopregnant rats. Injections of drugs in 20 μl oil were performed into the ovarian bursal cavity and repeated three times every 36 h. As compared with the control (oil-injected) group, the phospholipase A2 inhibitor dexamethasone (DEX) at the dose of 62.5 μg/ovary delayed functional luteolysis for 3 days by treatments from day 6 of pseudopregnancy (D6). Indomethacin (IND) also extended luteal activity for 5 days after treatment from D6, while nordihydroguaiaretic acid (NDGA) extended it for only 1 day. The extension of pseudopregnancy by each drug was not so evident with treatments from D2 or D4 as compared to that from D6. From D6, imidazole also delayed luteolysis, while a doubled dose of NDGA did not. Systemic administration of DEX or IND increased plasma progesterone levels more rapidly and significantly than local treatments but were less effective in delaying luteolysis. These results suggest that ovarian endogenous eicosanoids, mainly prostanoids, in the late luteal phase are involved in functional luteolysis in the present model.
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