Abstract
Mesenchymal stem cells therapy opened new perspective in the management of osteoarthritis. This study focuses on a randomized controlled trial pilot on 10 patients of osteoarthritis knees to evaluate the intra-articular injections of mesenchymal stem cells could improve the symptoms, functional limitation and regeneration of cartilage. Mesenchymal stem cells were obtained from peripheral blood after mobilization of blood cell with granulocyte colony stimulating factor by apheresis machine. Single dose of mesenchymal stem cells were injected into the affected joints, WOMAC questionnaires scale used to record pre and post-treatment improvement, cartilage thickness measured by high frequency ultrasonogram. Four patients were having Grade II and six were having Grade III osteoarthritis. Kellgren-Lawrence scale was used for radiological grading. Pain score were decreased at the end of 24th weeks from 14.8 ± 2.2 to 4.1 ± 1.3, Stiffness score decreased from 5.8 ± 0.6 to 0.7 ± 0.6, Physical function limitation score reduced from 46.7 ± 6.5 to 20.3 ± 2.5. There was minor improvement of range of motion and cartilage thickness changes. This study demonstrates that mesenchymal stem cells injections improves all parameters of knee osteoarthritis and minimal regeneration of damaged cartilage.
Highlights
Osteoarthritis is a degenerative process of the articular cartilage, involving the immune system, and producing local inflammatory reactions with production of pro-inflammatory cytokines and metalloproteinases
The recent report of World Health Organization indicates that osteoarthritis knee become the 4th most important cause of disability in women, and the 8th most important cause of disability in men.[6]
This randomized controlled trial pilot study was conducted on 10 patients of osteoarthritis knees from July to December, 2018
Summary
Osteoarthritis is a degenerative process of the articular cartilage, involving the immune system, and producing local inflammatory reactions with production of pro-inflammatory cytokines and metalloproteinases. The knee joint is frequently affected in Asian countries.[1, 2] The prevalence increases with age, women are suffering more than men.[3] It is the cause of disability among the elderly population.[4] It is an important financial burden for the global economy.[5]. Osteoarthritis of knees clinically manifested by joint pain, gelling stiffening, joint instability, difficulty to walking, jogging, squatting and stair climbing. A good number of patient present with quadriceps muscles wasting, difficulty to stand from sitting leading to physical disability, loss of functional capacity, reduces quality of life and increases the risk of other co-morbidity.[6] The recent report of World Health Organization indicates that osteoarthritis knee become the 4th most important cause of disability in women, and the 8th most important cause of disability in men.[6]
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