Abstract
目的 探讨IL-10区域动脉灌注(LAI)对急性胰腺炎(AP)大鼠血浆IL-6和TNF-α的影响.方法以5%牛磺胆酸钠胰胆管注射(1 ml/kg)制成大鼠急性胰腺炎模型,IL-10(40000 UI/kg)LAI,以生理盐水为对照,检测大鼠血浆IL-10、IL-6、TNF-α和淀粉酶.结果假手术组大鼠血浆IL-10测不出,IL-6、TNF-α和淀粉酶分别为(17.5±1.3) pg/ml、(71.25±5.75) pg/ml和(885.4±136.3) U/L,AP大鼠血浆IL-6、TNF-α明显升高,与假手术组对比有显著差异(P<0.05);IL-10 LAI则使AP大鼠血浆3 h和6h的IL-6、TNF-α明显降低,与生理盐水组及AP组对比均有显著差异(P<0.05),但12 h时二者明显升高,与生理盐水组及AP组对比均有显著差异(P<0.05),IL-10 LAI 使大鼠淀粉酶明显下降.结论 IL-10 LAI能降低AP大鼠3 h和6 h时的IL-6、TNF-α,但后期(12 h)则使二者升高,同时能降低AP大鼠淀粉酶,IL-10有望成为AP综合治疗的药物之一。
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