Abstract
Long Access self-administration procedures (LgA, 6hrs+/day) have become the gold-standard in the addiction field because they produce addiction-like behaviors, and changes in brain not seen following shorter drug access (1-2 hrs/day). However, Zimmer and colleagues recently developed an intermittent access self-administration procedure (IntA) to better model the patterns of cocaine use seen in addicts. IntA produces more robust addiction-like behaviors compared to LgA (cocaine-motivation, reinstatement, and cocaine-seeking) despite much less drug intake. Whether these distinct patterns of cocaine exposure produce similar or different alterations in nucleus accumbens (NAc) function is poorly understood, and there is limited understanding of the behavioral effects of IntA across sex.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
