Abstract

The key of skeletal muscle injuries is the homeostasis imbalance of Ca2+ in the skeletal muscle cells. Such imbalance can cause the significant changes of the biomarkers of skeletal muscle metabolism such as decreased superoxide dismutase (SOD), and increased malondialdehyde (MDA) and creatine kinase (CK). Measurements of these biomarkers can be used to evaluate the damage degree of human skeletal muscle cells (HSMCs) and their relation to Ca2+ level. Rolling manipulation is the most popular myofascial release technique in Traditional Chinese Medicine for patients with muscular dysfunctions, but it is still unknown how the rolling manipulation through its mechanic pressure to make biological effect on the local muscle tissue. Therefore, this study was to investigate the Ca2+ mediated effects of intermittent pressure imitating Rolling manipulation (IPIRM) of Traditional Chinese Medicine on the human skeletal muscle cells (HSMCs).

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