Effects of intensive insulin therapy on pancreatic β-cell function in newly diagnosed type 2 diabetes

Abstract

Objective To observe the effects of short-term intensive insulin therapy on pancreatic β-cell function in newly diagnosed type 2 diabetics.Methods Sixty newly diagnosed type 2 diabetes patients were randomly divided into two groups:intensive insulin therapy group (30 cases) and oral hypoglycemic agents group (30 cases),with a four weeks treatment.Before and after the treatment,blood glucose,plasma C-peptide and glycosylated hemoglobinAlc (HbAlc) were examined.Results After treatment,blood glucose and HbAlc of intensive group were decreased more obviously than those of control group,but C-peptide was obviously increased compared with before treatment (P ＜ 0.05).Whereas,compared with control group,blood glucose and HbA1c were lower and C-peptide of intensive insulin group was higher,the difference was significant (P ＜ 0.05).Conclusions In newly diagnosed type 2 diabetes,blood glucose can be controlled well and pancreatic β-cell function can be improved by intensive insulin therapy. Key words: Type 2 diabetes ; Insulin ; Pancreatic β-cell function ; C-peptide