Abstract
Intense pulsed light (IPL) has been used extensively in aesthetic and cosmetic dermatology. To test whether IPL could change the tissue vascularity and improve wound healing, mice were separated into 4 groups. Mice in Group I were not treated with IPL, whereas, dorsal skins of mice in Groups II, III, and IV were treated with 35 J/cm2, 25 J/cm2, and 15 J/cm2 IPL, respectively. After 2 weeks, dorsal island skin flaps were raised, based on the left deep circumflex iliac vessels as pedicles; then, survival rate was assessed. Flaps in Group IV (treated with lowest dose of IPL) have a survival rate significantly higher than other groups. Counting blood vessels did not demonstrate any significant differences; however, vessel dilation was found in this group. The results show that IPL at the therapeutic doses which are usually applied to humans is harmful to mouse dorsal skin and did not enhance wound healing, whereas, IPL at much lower dose could improve wound healing. The possible mechanism is the dilation of tissue vasculature thanks to the electromagnetic character of IPL. Another mechanism could be the heat-shock protein production.
Highlights
Wound healing impairment is often encountered in surgery
The middle portion of dorsal skin in the left was supplied by Groups and Intense pulsed light (IPL) treatment fluences
The results showed that the flap survival was significantly improved in the mice that had been treated with IPL fluences of 15 J/cm2—the lowest dose
Summary
Wound healing impairment is often encountered in surgery. There are many studies on this phenomenon, but many problems remain unknown and are subject to fierce debates.To study wound healing, many research models have been developed [1]. Wound healing impairment is often encountered in surgery. There are many studies on this phenomenon, but many problems remain unknown and are subject to fierce debates. Many research models have been developed [1]. The dorsal island skin flap model in the mouse has been used. This model has been pioneered by the author in the previous studies [2, 3]. The advantages and disadvantages of this model for wound healing study will be discussed along with relevant background information to help guide decision-making
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