Abstract
Objective To explore the effect of individualized nutritional intervention based on PG-SGA on the quality of life of gastric cancer patients with postoperative chemotherapy. Methods A total of 72 gastric cancer patients with postoperative chemotherapy were randomly divided into observation group (n=36) and control group (n=36) in Oncology Department, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School from August 2015 to January 2016. Patients in control group received routine nursing intervention based on NRS 2002 results while patients in observation group were cared by individualized nutritional intervention based on PG-SGA. EORTC quality of life (QLQ-C30) was applied to study the two groups before intervention and on 7th and 14th day after the intervention. Results Analysis of variance of repeated measures indicated that general health, physical function, role function, emotional function, cognitive function, social function, fatigue, pain, nausea and vomiting, loss of appetite were different before and after intervention (Ftime= 4.604, 7.541, 14.010, 15.975, 7.374, 4.681, 7.395, 19.313, 4.723, 5.807; P<0.05) . Overall health, physical function, loss of appetite, grading were different between observation group and control group (Fgroup= 5.124, 6.627, 12.355; P<0.05) . For decreased appetite, there was interaction between different time and group (Ftime×group= 4.579, P< 0.05) . Interaction effect outline of two groups before and after chemotherapy showed that, qulity of life of patients in the control group after chemotherapy declined on 7th day, and qulity of life on 14th was higher than that on 7th day. Patients of observation group had a higher quality of life on 7th and 14th day after chemotherapy compared that before chemotherapy. Conclusions Individualized nutritional intervention based on PG-SGA could elevate the overall quality of life for gastric cancer patients with postoperative chemotherapy, improve the symptoms of chemotherapy, physical function and appetite. Key words: Stomach neoplasms; Nutritional support; Quality of life; Chemotherapy; PG-SGA
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