Abstract
A plant’s response to the pioneer biological activities is the first step that it is used for therapeutic purposes. The antibacterial and antifungal properties of Melia azedarach L. (Indian Lilac) were investigated. As Indian Lilac is known for centuries as an antibacterial and antifungal agent, the main purpose of this study was to find is it effective against the most resilient human bacterial and fungal pathogens, which were collected from the different hospitals of Khyber Pakhtunkhwa. The crude extract was fractionated into five parts i.e. aqueous, chloroform, crude methanolic, ethyl acetate, and n-hexane. The fractions were then checked against most resistant strains of bacteria and fungi i.e. MRSA (Methicilline resistance Staphylococcus aurous), Serratia marcescense, Staphylococcus aurous, and Streptococcus mutans, for antibacterial activity and Alternaria alternate, Aspergillus flavous, Fusarium oxysporum, and polyspondylium pallidum for antifungal activity. Among all fractions, ethyl acetate was most effective against the selected pathogens showing the activity of i.e. (61-39%) and lowermost effectiveness shown by an aqueous fraction (47-30%) for bacterial pathogens. Regarding the antifungal activity, the most effective fraction was crude methanolic extracts (65-30%), and the least effective was fractions (20-10%). While the effectiveness of other selected fractions was in between the two. In conclusions of our experimentation, it is intensely supported, that Melia azedarach L. is even significant against most resilient strains of bacteria and fungi. Keywords: Antibacterial; antifungal; antimicrobial; Indian Lilac; Melia azedarach http://dx.doi.org/10.19045/bspab.2021.100104
Highlights
The use of plants as traditional utilize either plants or animals for cure medicine had been dated since the arrival of purposes
Regarding check the effectiveness of Melia azedarach L. as an anti-bacterial agent, five fractions were utilized and four bacterial strains i.e. Streptococcus mutans, Staphylococcus aurous, MRSA (Methicilline resistance Staphylococcus aurous), and Serratia marcescense were analyzed. The selection of these species for experimental purposes is because of their pathogenic nature and the pathogen are reported frequently during the investigation from hospitals of Khyber Pakhtunkhwa. All these species are the causative agent for different human diseases and we tested our extracts against these pathogenic species to determine their pathogenicity and find out cheap and efficacious treatment against these bacterial strains
Antibacterial potential of the crude extract of Melia Azedarach Crude methanolic extract inhibited the growth of MRSA with highest percentage of 52% followed by S. marcescens up to 47%, S. aureus with 46%, and S. mutans up to 39%. n-hexane fraction highly repressed the growth of S. marcescens with 52% which was followed by MRSA with 40%, S. mutans, and S. aureus with 35% and 34% respectively
Summary
The use of plants as traditional utilize either plants or animals for cure medicine had been dated since the arrival of purposes. Men of ancient times used plants humans on planet earth. Humans have no for food and as traditional medicines but with other options in case of their diseases but to time and advancements, the usage has been All the fractions obtained were concentrated by rotary evaporator and designate for that solvent fraction
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