Abstract
SummaryThirty-five patients with essential hypertension were treated with 2.5 mg indapamide daily for a period of 8 weeks following 2 weeks on placebo. Mean arterial blood pressures decreased from 188/108 mmHg supine (181/111 mmHg standing) to 153/91 mmHg (151/92 mmHg), the maximum effect being seen after 2 to 4 weeks. No side-effects were detected and all other parameters measured remained within the normal range. In a series of in vitro experiments to investigate the mode of action of the drug it was shown that in isolated rat aortic strips, noradrenaline and angiotensin II-stimulated contractions were decreased by increasing concentrations of indapamide in the bathing medium. In the frog skin sodium transport model, indapamide was shown, when added to the inner serosal side of the membrane, to produce a time and concentration-dependent decrease in potential difference and short-circuit current, and a reduction in the vasopressin response.
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