Abstract
Human severe combined immune deficiency (SCID) syndrome is a heterogeneous disease, and some SCID mutations are characterized by a high sensitivity to ionizing radiation (RS-SCID). This phenomenon is suspected to be due to impaired repair systems for damaged DNA [J. Exp. Med. 188 (1998) 627]. However, the details are not fully understood. In this work, two RS-SCID cell lines were conferred radioresistance by infection with a recombinant adenovirus encoding E6/ E7 (AxE67), and by transfection with an expression vector bearing human telomerase reverse transcriptase ( hTERT). Our findings suggest that overexpressed E6 and E7 or elevated telomerase activity have some influence on the acquired radioresistance in human RS-SCID cells.
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