Abstract
The effects of inanition, semistarvation, and protein-free diets on the partition of serum proteins in adult, male, Sprague-Dawley rats was investigated following weight losses of 12, 26, and 33%. The quantitative changes in the serum protein fractions under the various types of nutritional stress showed significant differences. The albumin, α1- and γ-globulin fractions decreased significantly in the rats on the starvation regimen, while the semistarvation diet caused major alterations in the α1- and ß-globulins. Feeding a protein-free diet elicited the greatest decline in total serum proteins, reflecting the changes in the albumin, α1-, and α2-globulin fractions. The conclusion was drawn that the electrophoretic fractions of serum do not respond in a uniform and nonspecific manner to diverse nutritional stresses.
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