Effects of in IL-1B/IL-1RN variants on the susceptibility to head and neck cancer in a chinese Han population

Yanhai Yin,Chunru Chen,Fen Li,Liangqian Tong,Bo Yuan

doi:10.1186/s12935-021-01750-0

Yanhai Yin, Chunru Chen + Show 3 more

Open Access

https://doi.org/10.1186/s12935-021-01750-0

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Abstract

BackgroundThe study aimed to evaluate the relationship of IL-1B/IL-1RN polymorphisms to the predisposition of head and neck cancer (HNC) in a Chinese Han population.MethodsNine single-nucleotide polymorphisms (SNPs) in IL-1B/IL-1RN were genotyped based on Agena MassARRAY platform. Logistic regression models were used to analyze the genetic association between these SNPs and HNC risk by calculating odds ratios (ORs) and 95% confidence intervals (CI). Haplotype analysis were performed using Haploview program and logistic regression model.ResultsThe genetic association between rs1143643 in IL-1B and the higher risk of HNC was found (OR = 1.23, 95% CI 1.04–1.46) in the overall. IL-1RN rs17042888 was related to a reduced risk of HNC in the subjects aged > 46 years (OR = 0.70, 95% CI: 0.50–0.98) and in females (OR = 0.71, 95% CI 0.52–0.98), while rs1143643 increased the predisposition of HNC among females (OR = 1.76, 95% CI 1.13–2.74). Furthermore, rs1143643 had an increased susceptibility to thyroid carcinoma (OR = 1.61, 95% CI 1.10–2.34). Moreover, compared with stage I–II, the frequency of IL-1RN rs452204-AG genotype was lower in patients with stage III–IV.ConclusionsIL-1B (rs1143643) and IL-1RN (rs17042888 and rs452204) polymorphisms might be related to the individual susceptibility of HNC in the Chinese Han population. These results might help to improve the understanding of IL-1B and IL-1RN genes in the occurrence of HNC.

Highlights

Head and neck cancer (HNC) is the sixth commonly diagnosed cancer worldwide, including cancers of oral cavity, nasopharynx, larynx, and salivary glands [1]
We explored the relationship of IL-1B/IL-1RN polymorphisms with clinical features of head and neck cancer (HNC), including HNC type, stage, and lymph nodes metastasis
We found that IL-1RN rs17042888 reduced the risk of HNC (GA vs. GG, odds ratios (ORs) = 0.70, 95% confidence intervals (CI) 0.50–0.98, p = 0.040) in subjects aged > 46 years

Summary

Introduction

Head and neck cancer (HNC) is the sixth commonly diagnosed cancer worldwide, including cancers of oral cavity, nasopharynx, larynx, and salivary glands [1]. Yin et al Cancer Cell Int (2021) 21:59. IL-1 family includes mainly of IL-1α, IL‐1β (pro‐inflammatory effect) and IL‐1 receptor antagonist (IL‐1RN, anti‐inflammatory effect). The tumor progression driven by IL-1 is related to the promotion of angiogenesis[10]. IL-1RN can target the tumor microenvironment by interfering in IL-1 biology[13]. Several studies have reported the relationship between genetic polymorphisms of IL-1 family genes and the risk of various cancers, including breast, gastric, colorectal, and cervical cancer [14,15,16], but HNC has not reported. The study aimed to evaluate the relationship of IL-1B/IL-1RN polymorphisms to the predisposition of head and neck cancer (HNC) in a Chinese Han population

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