Abstract
Objective To investigate the effect of imipenem cilastatin on pharmacokinetics in elderly patients with pulmonary infection. Methods Eighty-six elderly patients with pulmonary infection were selected, according to the order of filing, all the patients were divided into control group and study group, with 43 cases in each group. Patients in the control group were treated with cefoperazone sodium and sulbactam sodium, and patients in the study group were treated with imipenem cilastatin, the two groups were treated for 1 week. After the course of treatment, the clinical efficacy, bacterial clearance rates, incidences of adverse reaction between the two groups were compared, and the pharmacokinetic changes of imipenem and cilastatin in the study group were analyzed. Results The effective rate of the study group (95.35%)was higher than that of the control group (79.07%) , the difference was significant (P 0.05). Conclusions Imipenem and cilastatin treatment has significant effect on pulmonary infection in the elderly patients, high blood concentration of lung tissue, short half-life, which can effectively improve the treatment effect and the bacterial clearance rate, and has high safety, and has the value of popularization. Key words: Imipenem cilastatin; Pulmonary infection; Pharmacokinetics; Bacterial clearance rate
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
