Effects of imbalance of lipid metabolism through NF-KB pathway on atherosclerosis and vascular aging in rats.

Xiangyong Kong,Likun Ma,Dan Li,Hongwu Chen

doi:10.14715/cmb/2021.67.5.20

Xiangyong Kong, Likun Ma + Show 2 more

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https://doi.org/10.14715/cmb/2021.67.5.20

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Abstract

Cardiovascular diseases have become a mainstream disease by intensifying the country's population aging. The purpose of this article is to explore the specific effect and mechanism of lipid metabolism imbalance through the NF-KB pathway on atherosclerosis and vascular aging in rats. Twenty healthy adult rats were randomly divided into two groups, control in the observation group and the observation group. The rats in the observation group were fed a high-fat diet to imbalance the lipid metabolism of the rats. Immunohistochemistry and transmission electron microscope detectors were used to observe the NF-KB pathway in rats and study atherosclerosis-specific conditions of sclerosis and vascular aging. The results show that the imbalance of lipid metabolism through the NF-KB pathway can increase the rate of apoptosis in rat blood vessels by 24% and the proliferation rate by 18%. The number of vascular endothelial cell damage increased by 33%, which promoted atherosclerosis in rats and increased the rate of vascular aging in rats by 27%.

Highlights

Cardiovascular diseases have become a mainstream disease by intensifying the country's population aging
Analysis of the effect of lipid metabolism imbalance on atherosclerosis The study found that the imbalance of lipid metabolism can promote the occurrence and development of vascular complications by activating the NF-KB pathway, namely: increased activity of the NF-KB pathway, increased formation of end-products of advanced lipid metabolism, and nuclear factor-(NFKB)
The changes in atherosclerosis index (Table 2) under the imbalance of lipid metabolism can directly inhibit the proliferation of vascular endothelial cells (VEC), induce VEC apoptosis, and at the same time promote the expression of adhesion molecules, so that monocytes adhere to the arterial VEC

Summary

Introduction

Cardiovascular diseases have become a mainstream disease by intensifying the country's population aging. The purpose of this article is to explore the specific effect and mechanism of lipid metabolism imbalance through the NF-KB pathway on atherosclerosis and vascular aging in rats. The results show that the imbalance of lipid metabolism through the NF-KB pathway can increase the rate of apoptosis in rat blood vessels by 24% and the proliferation rate by 18%. This study is mainly to solve some problems in the detection technology and observation methods in the study of the effect of lipid metabolism imbalance through the NF-KB pathway on atherosclerosis and vascular aging in rats, so this article is carried out on the research content and detection methods. In order to improve and innovate, this article is the first to study the aging of vascular tissue and the expression of the NF-KB pathway in atherosclerosis animal models by immunohistochemistry and RT-PCR technology. This paper uses a new detection method to improve detection efficiency and accuracy, which is very helpful for subsequent research and analysis

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