Effects of Ilex paraguariensis A. St.-Hil. (Yerba Mate) and Chlorogenic Acid on Creatine Phosphokinase, Lactate and Irisin Levels in Mice after Detraining

Abstract

This is the first report that deals with the effect of yerba mate (YM) and chlorogenic acid (CGA) consumption on blood total creatine phosphokinase (CPK), lactate and irisin levels after a detraining period. Healthy mice (n = 50) were randomly separated into the following experimental groups: SED = sedentary control; TRAIN = mice submitted to training (swimming) for 8 weeks; DETRAIN = mice submitted to training for four weeks and after submitted to detraining for four weeks; DETRAIN CGA = mice submitted to training for four weeks and after submitted to both detraining and standard CGA consumption for four weeks; DETRAIN YM = mice submitted to training for four weeks and after submitted to both detraining and consumption of roasted YM infusion for four weeks. No significant (p > 0.05) difference was found in relation to the lactate value. The DETRAIN CGA group had a lower CPK data when compared with the other groups. The DETRAIN YM group showed a lactate value slightly lower than that from DETRAIN CGA one. Blood irisin value had no statistical (p > 0.05) difference between studied groups. Irisin value in sedentary group had a value non-statistically (p > 0.05) significant when compared with the other groups after a detraining period. Therefore, CGA could decrease the protein catabolism via CPK inhibition during detraining. YM may maintain a part of the lipid mobilization during detraining, leading to the sparing of a fraction of the lactate. Keywords: Ylex paraguariensis, mice, detraining, CPK, lactate, irisin