Abstract
Immunoglobulin G (IgG) is the commonest circulating antibody in humans. Cardiac IgG deposits and elevated circulating IgG levels have been observed in patients with left ventricular systolic and diastolic dysfunction, suggesting it may play a role in cardiac remodelling. Interestingly, commercially available IgG1 proteins are commonly used as an injectable isotype control in multiple animal models including those of heart failure. In this study, we aimed to determine whether these IgG1 isotype controls can have an effect on myocardial function in murine model of diet-induced cardiometabolic dysfunction.
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