Abstract
Objective: It has been shown that insulin-like growth factor-I (IGF-I) and transforming growth factor-α (TGF-α) are important inhibitors of cell death and promote preimplantation embryo development, and leukemia inhibitory factor (LIF) is implicated in 2inhibiting the differentiation of cells. Oct4 is a transcription factor that maintains totipotency of the cells and its effects were recently reported to be dependent on its concentration in the nucleus. Especially, oct4 mRNA and protein are predominantly found in the inner cell mass (ICM) of the blastocyst. This study was carried out to investigate the effects of IGF-I, TGF-α and LIF on Oct4 expression, in relation to the number of blastomere and apoptosis in mouse preimplantation embryos.
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