Effects of Ibuprofen and Indomethacin on Urinary Antidiuretic Hormone Excretion in Preterm Infants Treated for Patent Ductus Arteriosus

Abstract

Objective: To compare the effects of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on urinary antidiuretic hormone (ADH) excretion, as a cause of oliguria. Study Design: Forty-four respiratory distress syndrome prematures (≤34 weeks’ gestation) with PDA received either ibuprofen (n = 22) in an initial dose of 10 mg/kg followed by two doses of 5 mg/kg each after 24 and 48 h or three doses at 12-hour intervals of indomethacin (n = 24), 0.2 mg/kg, both infused continuously over a period of 15 min. Urinary ADH excretion, diuresis, serum creatinine, urinary sodium, fractional excretion of sodium, and urinary osmolality were measured before and after treatment. Results: Indomethacin treatment caused a significant decrease in urinary ADH excretion (21.8 ± 20.8 vs. 13.8 ± 12.9 pg/ml; p < 0.05), along with a significant reduction in urinary sodium (92.1 ± 36.1 vs. 64.8 ± 35.6; p < 0.05), fractional excretion of sodium (68.5 ± 37.1 vs. 45.6 ± 37.1; p < 0.05), and urinary osmolality (276.2 ± 103.9 vs. 226.4 ± 60.3; p < 0.05). Ibuprofen treatment did not modify urinary ADH excretion and caused a statistically insignificant decrease in urinary sodium and in fractional excretion of sodium. Conclusions: Compared with ibuprofen, indomethacin caused a significant reduction in urinary ADH excretion and a significant decrease in urinary sodium and osmolality.