Abstract
Hypoxia-inducible factor-1α (HIF-1α)is a transcription factor that acts as a master regulator of gene expression induced by low oxygen conditions. HIF-1α is the most sensitive indicator of hypoxia and can be activated by systemic hypoxia, cerebral hemisphere ischemia and cerebral focal ischemia. HIF-1 expression can be induced by hypoxic-ischemic damage after cerebral infarction and exert its effects on hypoxia-inducible downstream genes, thus protecting hypoxic tissues and cells under hypoxic conditions via regulating the expression of its downstream target genes. This article reviews the expression of HIF-1α and its downstream target genes in acute cerebral ischemia, in order to provide a theoretical basis for gene therapy. Key words: Hypoxia inducible factor 1, αsubunit; Cerebral ischemia; Reperfusion injury; Heat-shock proteins Hsp 90
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
