Abstract
Anesthetized and immobilized guinea pigs were subjected to hypothermia. During cooling, the cochlea: microphonics and endocochlear potential decreased and K + concentrations in both endolymph and perilymph were not significantly affected. The rate constant for K + turnover to endolymph was determined by uptake of 43K into the endolymph when the perilymphatic space was perfused with artificial perilymph containing 43K. The rate constant for K + decreased significantly in hypothermic guinea pigs when compared with that in normal guinea pigs. The K + conductance of the endolymph-perilymph barrier, estimated from the rate constant, showed a marked decrease in hypothermic guinea pigs and was comparable with the K conductance, calculated from the rate of change of the endolymph K + concentration relative to the K + electrochemical potential difference, recorded during permanent anoxia. These results suggest that hypothermia not only suppresses the active K + transport system but also decreases the K + permeability of the endolymph-perilymph barrier.
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